- Title
- Synthetic Routes to 3,4,5-Trihydroxypiperidines via Stereoselective and Biocatalysed Protocols, and Strategies to N- and O-Derivatisation
- Creator
- Prichard, Kate L.; O'Brien, Nicholas; Ghorbani, Mahdi; Wood, Adam; Barnes, Evan; Kato, Atsushi; Houston, Todd A.; Simone, Michela I.
- Relation
- European Journal of Organic Chemistry Vol. 2018, Issue 48, p. 6830-6842
- Publisher Link
- http://dx.doi.org/10.1002/ejoc.201801011
- Publisher
- Wiley-VCH Verlag GmbH & Co. KGaA
- Resource Type
- journal article
- Date
- 2018
- Description
- Stereoselective and biocatalysed synthetic routes to 3,4,5-trihydroxypiperidines and their N- and O-derivatisations are reviewed. These iminosugars effectively modulate glycosidase enzymes and display biological activities in immunosuppression, as anti-inflammatory agents and as anti-viral agents. Syntheses to these building blocks and their N- and O-derivatives are predicted to produce drug leads of high Fsp3 index. This is also crucial in the collection of structure-activity relationship data, particularly for diseases dependant on glycosidase modulation.
- Subject
- iminosugar; 3,4,5-trihydroxypiperidine; glyosidase; stereoselectivity; biocatalysis
- Identifier
- http://hdl.handle.net/1959.13/1441319
- Identifier
- uon:41388
- Identifier
- ISSN:1434-193X
- Language
- eng
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